Context Holy Quran has brought orders and decrees for the health and prevention of diseases for mankind which obey these rules ensure not only physical health but also mental health. The mighty god in Holy Quran has discouraged humans from drinking wine several times. The purpose of this study is deliberating alcohol effects on human health from the perspective of Holy Quran, and modern medicine. Evidence and Acquisition: In this paper by using proper keywords, an overview was made on Holy Quran, hadiths and scientific articles, available in Medline(Pubmed) and Embase as well as Persian sites such as SID and Magiran. Then effects of alcohol consumption on human health were analyzed. Results Holy Quran in four verses and infallible imams in several hadiths have prohibited alcohol consumption for humans. On the other hand, it leads to many socioeconomic and mental damages and results in detriments on the Central and Peripheral Nervous System. Cardiovascular System, Liver, Bone, Pancreas, Skin and Respiratory System are such organs and tissues in which bear loads of heavy irreversible injuries from alcohol consumption. Harmful effects of alcohol on fetus and causing different malignancy in several tissues are from other fatal effects which eventually lead to death. Conclusion Regarding Islam’s recommendations alcohol consumption is clearly forbidden. Scientific papers also express the damaging effects of alcohol on individual health which clearly demonstrates the same concept.

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